吴文帅

中共党员,研究生学历,博士学位,硕士生导师
邮箱:101013696@seu.edu.cn;课题组网站:https://www.x-mol.com/groups/wu_wenshuai

教育经历

2014.09至2019.06,于浙江大学生命科学学院,生物化学与分子生物学专业,获理学博士学位(直博);

攻读博士学位期间,参与学科交叉培养计划,于浙江大学控制科学与工程学院、工业控制技术国家重点实验室、分析仪器研究中心牟颖教授课题组从事生医工交叉领域研究。

科研与学术经历

1. 2024.01至 今,东南大学公共卫生学院,营养与食品卫生学,上岗副研究员(副教授)、硕士生导师

2. 2019.11至2023.04,新加坡 南洋理工大学,生物装置与生物信息学中心,博士后(合作导师为新加坡工程院院士)

研究方向

本课题组具有鲜明的多学科交叉研究特色,研究集中在研制高集成度、便携式微流体芯片,并以微流体芯片为载体,开发高灵敏度生化分析方法,用于癌症无创诊断,细菌感染检测和环境病原菌监测等领域。研究方向包括:

1.生物医学微流体装置

2.细菌感染及耐药性

3.食源性微生物检测

4.单分子光学传感器

欢迎具有生物学,医学,公共卫生,生物医学工程,人工智能,分析化学,食品科学,流体力学,微机电系统,微电子等专业背景或研究经历的人员加入。有意向者可发送邮件至:101013696@seu.edu.cn。请访问课题组网站(https://www.x-mol.com/groups/wu_wenshuai)了解更多信息。

主持或参加科研项目(课题)情况

主持:

1. 江苏省自然科学基金(青年项目),基于即用型微流体芯片的尿路病原菌快速药敏分析,20万元,2024.09-2027.08;

2. 工业控制技术全国重点实验室(开放课题),基于机器学习和微阵列芯片的多重病原菌数字化定量检测技术研究,7万元,2024.09-2026.09.

参与:

1. 新加坡卫生部项目MOH-000926, Screening of SARS-CoV-2 covalent entry inhibitors using photonic nanowell plate with single virus resolution, ~213万元, 核心研究人员

2. 新加坡国家水务局PUB-1804-0082, The integration optofluidic system for fast E. coli detectionin drinking water, ~1500万元, 核心研究人员

代表性研究成果和学术奖励情况

近年来,共发表期刊论文38篇,以第一/通讯作者在Advanced Functional Materials (IF=19),Biosensors and Bioelectronics (IF=12.6),Sensors and Actuators B: Chemical (IF=8.4),Analytical Chemistry (IF=7.4),Lab on a chip (IF=6.1),ACS Applied Material & Interface (IF=9.8),Journal of Water Process Engineering (IF=7),Analytica Chimica Acta (IF=6.2),Talanta (IF=6.1),Physics of Fluids (IF=4.6)等领域内权威期刊上发表研究论文20篇(15篇为中科院TOP期刊);研究工作得到Advanced Science News等多家媒体报道,并受邀到中科院苏州医工所作专题报告;授权国家发明专利2项,申请国家发明专利2项;担任Frontiers in Chemistry(IF=5.5)客座编辑。

代表性研究成果:

1. Wenshuai Wu; Simon Chun Kiat Goh; Gaozhe Cai; Shilun Feng; Boran Zhang; Digital metabolic activity assay enables fast assessment of 2D materials bactericidal efficiency, Analytica Chimica Acta, 2024, 1285: 342007.

2. Wenshuai Wu; Yuanjie Suo; Qianbin Zhao; Gaozhe Cai; Yang Liu; Wei Jin; Ying Mu; Boran Zhang; Inoculum size-insensitive susceptibility determination of urine sample based on in-situ measurement of inducible enzyme activity after 20 min of antibiotic exposure, Analytica Chimica Acta, 2023, 1282: 341858.

3. Wenshuai Wu; Boran Zhang; Weihong Yin; Liping Xia; Yuanjie Suo; Gaozhe Cai; Yang Liu; Wei Jin; Qianbin Zhao; Ying Mu; Enzymatic Antimicrobial Susceptibility Testing with Bacteria Identification in 30 min, Analytical Chemistry, 2023, 95(44): 16426-16432.

4. Wenshuai Wu; Gaozhe Cai; Yang Liu; Yuanjie Suo; Boran Zhang; Wei Jin; Yinghua Yu; Ying Mu ; Direct single-cell antimicrobial susceptibility testing of Escherichia coli in urine using a ready-touse 3D microwell array chip, Lab on a chip, 2023, 23(10), 2399-2410.

5. Wenshuai Wu; Binh Thi Thanh Nguyen; Patricia Yang Liu; Gaozhe Cai; Shilun Feng; Yuzhi Shi; Boran Zhang; Yuzhi Hong; Ruozhen Yu; Xiaohong Zhou; Ai Qun Liu; Yi Zhang; Eric Peng Huat Yap; Lip Ket Chin; Single Escherichia coli bacteria detection using a chemiluminescence digital microwell array chip, Biosensors and Bioelectronics, 2022, 215: 114594-114594.

6. Wenshuai Wu; Binh Thi Thanh Nguyen; Patricia Yang Liu; Gaozhe Cai; Shilun Feng; Yuzhi Shi; Boran Zhang; Yuzhi Hong; Ruozhen Yu; Xiaohong Zhou; Yi Zhang; Eric Peng Huat Yap; Ai Qun Liu; Lip Ket Chin; A self-driven carbon-doped high-density microwell array for single cell analysis, Sensors and Actuators B-chemical, 2022, 368: 132198-132198.

7. Wenshuai Wu; Qianbin Zhao; Gaozhe Cai; Boran Zhang; Yuanjie Suo; Yang Liu; Wei Jin; Ying Mu; All-In-One Escherichia coli Viability Assay for Multi-dimensional Detection of Uncomplicated Urinary Tract Infections, Analytical Chemistry, 2022, 94(51): 17853-17860.

8. Wenshuai Wu; Shan Zhang; Tao Zhang; Ying Mu; Immobilized Droplet Arrays in Thermosetting Oil for Dynamic Proteolytic Assays of Single Cells, ACS Applied Materials & Interfaces, 2021, 13(5): 6081-6090

9. Wenshuai Wu; Fengtian Wu; Shan Zhang; Xiong Ding; Tao Zhang; Ying Yang; Ying Mu; A self-powered bidirectional partition microfluidic chip with embedded microwells for highly sensitive detection of EGFR mutations in plasma of non-small cell lung cancer patients, Talanta, 2020, 220: 121426.

10. Wu, Wenshuai; Zhou, Shufang; Hu, Jiumei; Wang, Guoping; Ding, Xiong; Gou, Tong; Sun, Jingjing; Zhang, Tao; Mu, Ying; A Thermosetting Oil for Droplet-Based Real-Time Monitoring of Digital PCR and Cell Culture, Advanced Functional Materials, 2018, 39(28): 1803559.

更多信息请关注Researchgate主页:https://www.researchgate.net/profile/Wenshuai_Wu