教育经历
1. 2007/09 - 2012/06，南京医科大学，劳动卫生与环境卫生学系，博士（硕博连读）
2. 2002/09 - 2007/06，南京医科大学，预防医学系，学士
科研与学术经历
1. 2019/11 - 至今，东南大学“仲英青年学者”
2. 2017/04 - 至今，东南大学，劳动卫生与环境卫生学系，副教授，博士生导师
3. 2012/09 – 2017/04，东南大学，劳动卫生与环境卫生学系，讲师
研究方向
1.肿瘤分子流行病学
2.环境与职业病发病机制
主持或参加科研项目（课题）情况
1.东南大学“仲英青年学者”，2020/01-2022/12，30万元，在研，主持
2.国家自然科学基金面上项目，81872684，MiR-143/145宿主基因CARMN低表达参与宫颈癌遗传易感及其机制研究，2019/01-2022/12，57万元，在研，主持
3.江苏省自然科学基金面上项目，BK20171367，LncRNA MIR143HG及其遗传变异与宫颈癌易感性的机制研究，2017/07-2020/06，10万元，在研，主持
4.国家自然科学青年基金项目，81302502，miR-143基因启动子区遗传变异影响基因转录调控机制及与宫颈癌发生危险性的研究，2014/01-2016/12，23万元，已结题，主持
5.江苏省自然科学青年基金项目，BK20130641，miR-21基因启动子区多态变异与宫颈癌遗传易感性及其机制探讨，2013/07-2016/6，20万元，已结题，主持
6.教育部博士点基金（新教师类），20130092120063，miR-143基因启动子区多态变异与宫颈癌遗传易感性的研究，2014/01-2016/12，4万元，已结题，主持
代表性研究成果和学术奖励情况
代表性研究成果：
1. Wang Shizhi*, Ding Bo, Cui Mengjing, Yan Wenjing, Xia Qianqian, Meng Dan, Shen Siyuan, Xie Shuqian, Jin Hua, Zhang Xing*. Fanconi Anemia Pathway Genes Advance Cervical Cancer via Immune Regulation and Cell Adhesion. Front Cell Dev Biol. 2021 Nov 15;9:734794.
2. Zhu Chuanhui#, Xia Qianqian#, Gu Bin, Cui Mengjing, Zhang Xing, Yan Wenjing, Meng Dan, Shen Siyuan, Xie Shuqian, Li Xueliang*, Jin Hua*, Wang Shizhi*. Esophageal Cancer Associated Immune Genes as Biomarkers for Predicting Outcome in Upper Gastrointestinal Tumors.Front Genet. 2021 Jul 19;12:707299.
3. Meng Dan#, Jin Hua#, Zhang Xing, Yan Wenjing, Xia Qianqian, Shen Siyuan, Xie Shuqian, Cui Mengjing, Ding Bo, Gu Yun*, Wang Shizhi*. Identification of autophagy-related risk signatures for the prognosis, diagnosis, and targeted therapy in cervical cancer. Cancer Cell Int. 2021 Jul 8;21(1):362.
4. Yan Wenjing#, Jin Hua#, Zhang Xing, Long Sigui, Xia Qianqian, Meng Dan, Ding Bo, Li Dake, Ma Jingru, Cao Jian*, and Wang Shizhi*. Identification of an immune signature to predict poor clinical outcome in cervical cancer. Epigenomics. 2021 Jun;13(11):891-907.
5. Xia Qianqian#, Jin Hua #, Zhang Xing, Yan Wenjing, Meng Dan, Ding Bo, Cao Jian, Li Dake*, Wang Shizhi*. Prognosis prediction signature of seven immune genes based on HPV status in cervical cancer. International Immunopharmacology. 2020; 88:106935
6. Zhang Yan, Zhang Xing, Zhu Haixia, Liu Yang, Cao Jian, Li Dake, Ding Bo, Yan Wenjing, Jin Hua*, Wang Shizhi*. Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer. Cancer Management and Research. 2020;12: 719-730.
7. Wang Shizhi*, Zhu Haixia, Ding Bo, Feng Xinrui, Zhao Wenxuan, Cui Mengjing, Xu Yuling, Shi Minxing, Chen Jian, Jin Hua*. Genetic variants in microRNAs are associated with cervical cancer risk. Mutagenesis. 2019 May 29;34(2):127-133.
8. Gu Bin, Li Meng, Zhang Yan, Li Lingyun, Yao Kun, Wang Shizhi*. DR7 encoded by human herpesvirus 6 promotes glioma development and progression. Cancer Management and Research. 2019 Mar 12;11:2109-2118.
9. Li Xiuting, Dong Qiu, Wang Boshen, Song Haiyan, Wang Shizhi*, Zhu Baoli*. The Influence of Occupational Noise Exposure on Cardiovascular and Hearing Conditions among Industrial Workers. Scientific Reports. 2019;9:11524
10. Gu Bin, Li Lingyun, Li Meng, Wang Jinfeng, Zhang Guofeng, Yao Kun, Wang Shizhi*. U94/rep of human herpesvirus 6 inhibits proliferation, invasion, and angiogenesis of glioma. Cancer Management and Research. 2018 Nov 20;10:5991-6001.
11. Jin Hua#, Lu Xiaoyun#, Ni Jing#, Sun Jinfang, Gu Bin, Ding Bo, Zhu Haixia, Ma Chao, Cui Mengjing, Xu Yuling, Zhang Zhengdong, Lercher Martin, Chen Jian*, Gao Na*, Wang Shizhi*, HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population [J]. Scientific Reports. 2017, 7(1):3144.
12. Meng Qingtao#, Wang Shizhi#, Tang Weiyan#, Wu Shenshen, Gao Nao, Zhang Chengcheng, Cao Xiaoli, Li Xiaobo, Zhang Zhengdong, Aschner Michael, Jin Hua*, Huang Yue*, Chen Rui*. XRCC1 mediated the development of cervival cancer through a novel Sp1/Krox-20 swich. Oncotarget. 2017 Sep 16;8(49):86217-86226.
13. Wu Shenshen#, Wang Shizhi#, Fu You, Tang Weiyan, Jin Hua, Meng Qingtao, Zhang Chengcheng, Cui Mengjing, Cao Xiaoli, Li Xiaobo, Zhang Zhengdong, Chen Rui*, A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPbeta and OCT1 complex to chromatin [J]. International Journal of Cancer, 2017, 140(4): 756-763.
14. Wang Shizhi#, Ma Gaoxiang#, Zhu Haixia#, Lv Chunye#, Chu Haiyan, Tong Na, Wu Dongmei, Qiang Fulin, Gong Weida, Zhao Qinghong, Tao Guoquan, Zhou Jianwei, Zhang Zhengdong*, Wang Meilin*, miR-107 regulates tumor progression by targeting NF1 in gastric cancer [J]. Scientific Reports, 2016, 6: 36531.
15. Wang Shizhi*, Cao Xiaoli, Ding Bo, Chen Jinfeng, Cui Mengjing, Xu Yuling, Lu Xiaoyun, Zhang Zhengdong, He Aiqin, Jin Hua*, The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population [J]. Gene, 2016, 595(1): 109-114.
16. Wang Shizhi, Wu Shenshen, Zhu Haixia, Ding Bo, Cai Yunlang, Ni Jing, Wu Qiang, Meng Qingtao, Zhang Xin, Zhang Chengcheng, Li Xiaobo, Wang Meilin, Chen Rui*, Jin Hua*, Zhang Zhengdong*, PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population [J]. Scientific Reports, 2016, 6: 23465.
17. Wang Shizhi, Wu Shenshen, Meng Qingtao, Li Xiaobo, Zhang Jinchun, Chen Rui*, Wang Meilin*, FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin, Scientific Reports, 2016, 6: 19229.
18. Wang Shizhi, Lv Chunye, Jin Hua, Xu Ming, Kang Meiyun, Chu Haiyan, Tong Na, Wu Dongmei, Zhu Haixia, Gong Weida, Zhao Qinghong, Tao Guoquan, Zhou Jianwei, Zhang Zhengdong*, Wang Meilin, A common genetic variation in the promoter of miR-107 is associated with gastric adenocarcinoma susceptibility and survival, Mutation Research, 2014, 769: 35-41.
19. Wang Shizhi, Chen Lulu, Zhao Qinghong, Rong Huan, Wang Meilin, Gong Weida, Zhou Jianwei, Wu Dongmei, Zhang Zhengdong*, Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy, Cancer Chemother Pharmacol, 2013, 71(4): 1073-1082.
20. Wang Shizhi, Tao Guoquan, Wu Dongmei, Zhu Haixia, Gao Yan, Tan Yongfei, Wang Meilin, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, A functional polymorphism in MIR196A2 is associated with risk and prognosis of gastric cancer, Mol Carcinog, 2013, 52 Suppl 1: E87-95.
21. Shi Danni#, Wang Shizhi#, Gu Dongying#, Wu Dongmei, Wang Meilin, Chu Haiyan, Tong Na, Ma Lan, Zhong Dongyan, Zhang Zhengdong*, The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis, J Cancer Res Clin Oncol, 2012, 138(8): 1339-1345.
22. Wang Shizhi, Tian Yuanyuan, Wu Dongmei, Zhu Haixia, Luo Dewei, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population, Mutagenesis, 2012, 27(6): 623-630.
23. Wang Shizhi, Tang Jialin, Wang Meilin, Yuan Lin, Zhang Zhengdong*, Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population, Carcinogenesis, 2010, 31(4): 621-624.
# & * indicate co-first author and co-corresponding author, respectively.
学术奖励：
1.大连东岗奖教金
2.江苏省抗癌协会“江苏肿瘤医学科学技术奖励”三等奖